Publications Richard Voellmy

Voellmy R, Bloom DC, Vilaboa N (2020) Herpes simplex viruses whose replication can be deliberately controlled as candidate vaccines. Vaccines 8: 230

Vilaboa N, Martín-Saavedra F, Escudero-Duch C, Prieto M, Sánchez-Casanova S, Lopez D, Arruebo M, Voellmy R, Santamaria J (2018) Pro-angiogenic near infrared-responsive hydrogels for deliberate transgene expression. Acta Biomater 78: 123-136

Bloom DC, Tran RK, Feller J, Voellmy R (2018) Immunization by replication-competent controlled herpesvirus vectors. J Virol 92(16): e00616-18

Voellmy R, Zürcher O, Zürcher M, de Viragh PA, Hall AK, Roberts SM (2018) Targeted heat activation of HSP promoters in the skin of mammalian animals and humans. Cell Stress Chaperones 23(4): 455-466

Vilaboa N, Boré A, Martin-Saavedra F. Bayford M, Winfield N, Firth-Clark S, Kirton SB, Voellmy R (2017) New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival. Nucleic Acids Res 45: 5797-817

Voellmy R, Bloom DC, Vilaboa N, Feller J (2017) Development of recombinant HSV-based vaccine vectors. Methods Mol Biol 1581: 55-78

Bloom DC, Feller J, McAnany P, Vilaboa N, Voellmy R (2015) Replication-competent controlled herpes simplex virus. J Virol 89: 10668-79

Voellmy R, Bloom DC, Vilaboa N (2015) Immunization by replication-competent, controlled viral pathogen – A novel approach worth exploring for diseases refractory to effective conventional vaccination? J Vaccines Vaccin 6: 286

Vilaboa N, Voellmy R (2015) Deliberate regulation of therapeutic transgenes: recent advances in system development and uses. In: Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fourth Edition (Smyth Templeton N, ed.) CRC Press, Boca Raton, FL, pp. 628-75

Voellmy R, Bloom DC, Vilaboa N (2015) A novel approach for addressing diseases not yielding to effective vaccination? Immunization by replication-competent controlled virus. Expert Rev Vaccines 14: 637-51

Martin-Saavedra FM, Cebrian V, Gomez L, Lopez D, Arruebo M, Wilson CG, Franceschi RT, Voellmy R, Santamaria J, Vilaboa N (2014) Temporal and spatial patterning of transgene expression by near-infrared irradiation. Biomaterials 35: 8134-43

Wilson CG, Martín-Saavedra FM, Padilla F, Fabiilli ML, Zhang M, Baez AM, Bonkowski CJ, Kripfgans OD, Voellmy R, Vilaboa N, Fowlkes JB, Franceschi RT (2014) Patterning Expression of Regenerative Growth Factors Using High Intensity Ultrasound. Tissue Eng Part C Methods 20:769-79

Martin-Saavedra FM, Wilson GC, Voellmy R, Vilaboa N, Franceschi RT (2013) Spatiotemporal control of vascular endothelial growth factor expression using a heat shock-activated, rapamycin-dependent gene switch. Hum Gene Ther Methods 24: 160-70

Zhao Y, Liu H, Liu Z, Ding,Y, Ledoux SP, Wilson GL, Voellmy R, Lin Y, Lin W, Nahta R, Liu B, Fodstad O, Chen J, Wu Y, Price JE, Tan M (2011) Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism. Cancer Res 71: 4585-97

Vilaboa N, Boellmann F, Voellmy R (2011) Gene switches for deliberate regulation of transgene expression: recent advances in system development and uses. J Genet Syndr Gene Ther 2: 107. Doi:10.4172/2157-7412.1000107

Vilaboa N, Voellmy R (2009) Deliberate regulation of therapeutic transgenes. In: Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Third Edition (Smyth Templeton N, ed.) CRC Press, Boca Raton, FL, pp. 619-36

Jimenez J, Roberts SM, Mejia J, Mauro L, Munson J, Elgart GW, Alvarez Conelly E, Chen Q, Zou J, Goldenberg C, Voellmy R (2008) Prevention of chemotherapy-induced alopecia in rodent models. Cell Stress Chaperones 13: 31-8

Voellmy R (2007) HSF1 and hsp gene regulation. In: Cell Stress Proteins (SK Calderwood, ed.) Protein Reviews, volume 7. Springer, New York, pp. 122-40

Voellmy R, Boellmann F (2007) Chaperone regulation of the heat shock protein response. Adv Exp Med Biol 594: 89-99

Vilaboa N, Voellmy R (2006) Regulatable gene expression systems for gene therapy, Curr. Gene Ther 6: 421-38

Tolson JK, Dix DJ, Voellmy RW, Roberts SM (2006) Increased hepatotoxicity of acetaminophen in Hsp70i knockout mice, Toxicol Appl Pharmacol 210: 157-62

Voellmy R (2006) Feedback regulation of the heat shock response. Handb Exp Pharmacol (172): 43-68

Vilaboa N, Fenna M, Munson J, Roberts SM, Voellmy R (2005) Novel gene switches for targeted and timed expression of proteins of interest. Mol Ther: 12: 290-8

Guettouche T, Boellmann F, Lane WS, Voellmy R (2005) Analysis of phosphorylation of human heat shock factor 1 in severely heat-stressed cells, BMC Biochemistry 6: 4

Voellmy R (2005) The stress protein response: consequences of stress exposure – cytoprotection – potential diagnostic and therapeutic applications. Methods 35: 115-6

Voellmy R (2005) Dominant-positive and dominant-negative heat shock factors. Methods 35: 199-207

Voellmy R (2004) On mechanisms that control heat shock transcription factor activity in metazoan cells. Cell Stress Chaperones 9: 122-33

Voellmy R (2004) Transcriptional regulation of the metazoan stress protein response. Prog Nucleic Acid Res Mol Biol 78: 143-85

Gough MJ, Melcher AA, Crittenden MR, Sanchez-Perez L, Voellmy R, Vile RG (2004) Induction of cell stress through gene transfer of an engineered heat shock transcription factor enhances tumor immunogenicity. Gene Ther 11: 1099-104

Boellmann F, Guettouche T, Guo Y, Fenna M, Mnayer L, Voellmy R (2004) DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity. Proc Natl Acad Sci USA 101: 4100-5

Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M (2004) CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet 13: 703-14

Xia W, Hardy L, Liu L, Zhao S, Goodman M, Voellmy R, Spector NL (2003) Concurrent exposure to heat shock and H7 synergizes to trigger breast cancer cell apoptosis while sparing normal cells. Breast Cancer Res Treat 77: 233-43

Guo Y, Guettouche T, Fenna M, Boellmann F, Pratt WB, Toft DO, Smith DF, Voellmy R (2001) Evidence for a Mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. J Biol Chem 276: 45791-9

Winklhofer KF, Reintjes A, Hoener MC, Voellmy R, Tatzelt J (2001) Geldanamycin restores a defective heat shock response in vivo. J Biol Chem 276: 45160-7

Emiliusen L, Gough M, Bateman A, Ahmed A, Voellmy R, Chester J, Diaz RM, Harrington K, Vile R (2001) A transcriptional feedback loop for tissue-specific expression of highly cytotoxic genes which incorporates an immunostimulatory component. Gene Ther 8: 987-98

Xia W, Voellmy R, Spector N (2000) Sensitization of tumor cells to fas kiling through overexpression of heat-shock transcription factor 1. J Cell Physiol 183: 425-31

Xia W, Vilaboa N, Martin J, Mestril R, Guo Y, Voellmy R (1999) Modulation of tolerance by mutant heat shock transcription factors, Cell Stress Chaperones 4: 8-18

Tatzelt J, Voellmy R, Welch WJ (1998) Abnormalities in stress proteins in prion diseases, Cellular and Molecular Neurobiology 18: 721-9

Wagstaff MJD, Collaco-Moraes Y, de Belleroche JS, Coffin RS, Voellmy R, Latchman DS (1998) Delivery of a constitutively active form of the heat shock transcription factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosis, Eur J Neuroscience 10: 3343-50

Zou J, Guo Y, Guettouche T, Smith DO, Voellmy R (1998) Repression of heat shock transcription factor HSF1 by Hsp90 (Hsp90 complex) that forms a stress-sensitive complex with HSF1, Cell 94: 471-80

Salminen WF, Voellmy R, Roberts SM (1998) Effect of N-acetyl-cysteine on heat shock protein induction by acetaminophen in mouse liver. J Pharmacol Exp Ther 286: 519-24

Zou J, Salminen WF, Roberts SM, Voellmy R (1998) Correlation between glutathione oxidation and trimerization of heat shock factor 1, an early step in the stress induction of the Hsp response. Cell Stress Chaperones 3: 130-41

Xia W, Guo W, Zuo J, Voellmy R (1998) Transcriptional activation of heat shock factor 1 probed by in vivo phosphopeptide mapping. J Biol Chem.273: 8749-55

Salminen WF, Voellmy R, Roberts SM (1997) Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein induction. Toxicol Appl Pharmacol 147: 247-58

Salminen WF, Voellmy R, Roberts SM (1997) Differential heat shock protein induction by acetaminophen and a non-hepatotoxic regioisomer, 3’-hydroxyacetanilide, in mouse liver. J Pharmacol Exp Ther 282: 1533-40

Hardy L, Goodman M, Vasquez A, Chauhan D, Anderson KC, Voellmy R, Spector N (1997) Activation signals regulate heat shock transcription factor 1 in human B lymphocytes. J Cell Physiol 170: 235-40

Xia W, Voellmy R (1997) Hyperphosphorylation of heat shock transcription factor 1 is correlated with transcriptional competence and slow dissociation of active factor trimers. J Biol Chem 272: 4094-102

Salminen WF, Roberts SM, Fenna M, Voellmy R (1997) Heat shock protein induction in murine liver after acute treatment with cocaine. Hepatology 25: 1147-53

Voellmy R (1996) Sensing and responding to stress. In: Stress-inducible Cellular Responses (Feige U, Morimoto RI, Yahara I, Polla B, eds.) Birkhauser Verlag, Basel, Boston, Berlin, pp. 121-37

Voellmy R (1996) Review of patents in the cell stress and chaperone field. Cell Stress Chaperones 1: 29-32

Baler R, Zou J, Voellmy R (1996) Evidence for a role of hsp70 in the regulation of the heat shock response in mammalian cells. Cell Stress Chaperones 1: 33-39

Salminen WF, Voellmy R, Roberts SM (1996) Induction of hsp70 in HepG2 cells in response to hepatotoxicants. Toxicol Appl Pharmacol 141: 117-23

Hedge RS, Zuo J, Voellmy R, Welch WJ (1995) Short circuiting stress protein expression via a tyrosine kinase inhibitor, herbimycin A. J Cell Physiol 165: 186-200

Zuo J, Rungger D, Voellmy R (1995) Multiple layers of regulation of human heat shock transcription factor 1. Mol Cell Biol 15: 4319-30

Black N, Voellmy R, Szmant AM (1995) Heat shock protein induction in Montastrea faveolata and Aiptasia pallida exposed to elevated temperatures. Biological Bulletin 188: 234-40

Tatzelt J, Voellmy R, Zuo J, Scott M, Hartl U, Prusiner SB, Welch WJ (1995) Scrapie prions selectively modify the heat shock response in neuroblastoma cells. Proc Natl Acad Sci USA 92: 2944-8

Zuo J, Baler R, Dahl G, Voellmy R (1994) Activation of DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular coiled-coil structure. Mol Cell Biol 14: 7557-68

Voellmy R (1994) Transduction of the stress signal and mechanisms of transcriptional regulation of heat shock or stress protein gene expression in higher eukaryotes. CRC Crit Rev Eukaryotic Gene Expression 4: 357-401

Amin J, Fernandez M, Ananthan J, Lis JT, Voellmy R (1994) Cooperative binding of heat shock transcription factor to the hsp70 promoter in vivo and in vitro. J Biol Chem 269: 4804-11

Baler R, Dahl G, Voellmy R (1993) Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1. Mol Cell Biol 13: 2486-96

Ananthan J, Baler R, Morrissey D, Zuo J, Lan Y, Weir M, Voellmy R (1993) Synergistic activation of transcription is mediated by the N-terminal domain of Drosophila fushi tarazu homeoprotein and can occur without DNA binding by the protein. Mol Cell Biol 13: 1599-609

Schiller P, Geffin R, Voellmy R (1992) Rapid complementation assay for anti-HIV-1 drug screening and analysis of envelope protein function. AIDS Res Hum Retroviruses 8: 1723-31

Baler R, Welch WJ, Voellmy R (1992) Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor. J Cell Biol 117: 1151-59

Amin J, Mestril R, Voellmy R (1991) Genes for Drosophila small heat shock proteins are regulated differently by ecdysterone. Mol Cell Biol 11: 5937-44

Luo Y, Amin J, Voellmy R (1991) Ecdysterone receptor is a sequence-specific transcription factor involved in the developmental regulation of heat shock genes. Mol Cell Biol 11: 3660-75

Voellmy R, Luo Y, Mestril R, Amin J, Ananthan, J. (1991) Mechanism of regulation of small heat shock protein genes in Drosophila. In: Heat Shock (Maresca B,  Lindquist SL, eds.) Springer Verlag Heidelberg, FRG

Goff SA, Voellmy R, Goldberg AL (1988) Protein breakdown and the heat shock response. In: Ubiquitin (Rechsteiner M, ed.) Plenum, New York, pp. 207-

Amin J, Ananthan J, Voellmy R (1988) Key features of heat shock regulatory elements. Mol Cell Biol 8: 3761-9

Goldenberg CJ, Luo Y, Fenna M, Baler R, Weinmann R, Voellmy R (1988) Purified human factor activates heat shock promoter in a HeLa cell-free transcription system. J Biol Chem 263: 18734-9

Schiller P, Amin J, Ananthan J, Brown ME, Scott WA, Voellmy R (1988) Cis-acting elements involved in the regulated expression of a human hsp70 gene. J Mol Biol 203: 97-105

Brown ME, Amin J, Schiller P, Voellmy R, Scott WA (1988) Determinants for the Dnase I – hypersensitive chromatin structure 5’ to a human hsp70 gene. J Mol Biol 203: 107-17

Simon MC, Kitchener K, Kao HT, Hickey E, Weber L, Voellmy R, Heintz N, Nevins JR (1987) Selective induction of human heat shock gene transcription by the adenovirus E1A gene products, including the 13S product. Mol Cell Biol 7: 2884-90

Dahl G, Miller T, Paul D, Voellmy R, Werner R (1987) Expression of functional cell-cell channels from cloned rat liver gap junction complementary DNA. Science 236: 1290-3

Amin J, Mestril R, Schiller P, Dreano M, Voellmy R (1987) Organization of the Drosophila melanogaster hsp70 heat shock regulation unit. Mol Cell Biol 7: 1055-62

Dreano M, Brochot J, Myers A, Cheng-Meyer C, Rungger D, Voellmy R, Bromley P (1986) High-level, heat-regulated synthesis of proteins in eukaryotic cells. Gene 49: 1-8

Mestril R, Schiller P, Amin J, Klapper H, Ananthan J, Voellmy R (1986) Heat shock and ecdysterone activation of the Drosophila melanogaster hsp23 gene: a sequence element implied in developmental regulation. EMBO J 5: 1667-73

Ananthan J, Goldberg AL, Voellmy R (1986) Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes. Science 232: 522-4

Mestril R, Rungger D, Schiller P, Voellmy R (1985) Identification of a sequence element in the promoter of the Drosophila melanogaster hsp23 gene that is required for its heat activation. EMBO J 4: 2971-6

Goldberg AL, Voellmy R, Chung CH, Menon AS, Desautels M, Meixsell T, Waxman L (1985) The ATP-dependent pathway for protein breakdown in bacteria and mitochondria. Prog Clin Biol Res 180: 33-45

Voellmy R, Ahmed A, Schiller P, Bromley P, Rungger D (1985) Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment. Proc Natl Acad Sci USA 82: 4949-53

Lawson R, Mestril R, Luo Y, Voellmy R (1985) Ecdysterone selectively stimulates expression of a 23000-Da heat-shock protein-beta-galactosidase hybrid gene in cultured Drosophila cells. Dev Biol 110: 321-30

Amin J, Mestril R, Lawson R, Klapper H, Voellmy R (1984) The heat shock consensus sequence is not sufficient for hsp70 gene expression in Drosophila melanogaster. Mol Cell Biol 5: 197-203

Lawson R, Mestril R, Schiller P, Voellmy R (1984) Expression of heat shock-beta-galactosidase hybrid genes in cultured Drosophila cells. Mol Gen Genet 198: 116-24

Voellmy R (1984) The heat shock genes: a family of highly conserved genes with a superbly complex expression pattern. BioEssays 1: 213-7

Voellmy R, Lawson R, Mestril R, Schiller P (1984) In: Advances in Gene Technology: Human Genetic Disorders (Ahmad F, Black S, Schultz J, Whelan W, eds.) ICSU Short Reports 1: 40-4

Southgate R, Ayme A, Voellmy R (1983) Nucleotide sequence analysis of the Drosophila small heat shock gene cluster at locus 67B. J Mol Biol 165: 35-57

Voellmy R, Bromley P, Kocher HP (1983) Structural similarities between corresponding heat-shock proteins from different eukaryotic cells. J Biol Chem 258: 3516-22

Voellmy R, Bromley PA (1982) Massive heat-shock polypeptide synthesis in late chicken embryos: convenient system for study of protein synthesis in highly differentiated organisms. Mol Cell Biol 2: 479-83

Voellmy R, Rungger D (1982) Heat-induced transcription of Drosophila heat shock genes in Xenopus oocytes. In: Heat Shock from Bacteria to Man (Schlesinger M, Ashburner M, Tissieres A, eds.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., pp. 49-56

Voellmy R, Rungger D (1982) Transcription of a Drosophila heat shock gene is heat-induced in Xenopus oocytes. Proc Natl Acad Sci USA 79: 1776-80

Bromley PA, Voellmy R, Spahr PF (1981) Hybrid plasmids carrying part of the Rous sarcoma virus-specific leader sequence. Biochim Biophys Acta 655: 41-8

Voellmy R, Goldschmidt-Clermont M, Southgate R, Tissieres A, Levis R, Gehring W (1981) A DNA segment isolated from chromosomal site 67B in D. melanogaster contains four closely linked heat-shock genes. Cell 23: 261-70

Voellmy R, Goldberg AL (1981) ATP-stimulated endoprotease is associated with the cell membrane in E. coli. Nature 290: 419-21

Voellmy R, Goldberg AL (1980) Guanosine-5’-diphosphate-3’-diphosphate (ppGpp) and the regulation of protein breakdown in Escherichia coli. J Biol Chem 255: 1009-14

Murakami K, Voellmy R. Goldberg AL (1979) Protein degradation is stimulated by ATP in extracts of Escherichia coli. J Biol Chem 254: 8194-200

Goldberg AL, Voellmy R, Swami KHS (1979) Studies of the pathway of protein degradation in E. coli and mammalian cells. In: Biological Functions of Proteinases (Holzer H, Tschesche H, eds.) Springer Verlag Germany, pp. 35-48

Voellmy R, Murakami K, Goldberg AL (1979) The ATP-dependent degradation of proteins in Escherichia coli and mammalian cells. In: Limited Proteolysis in Microorganisms (Cohen GN, Holzer H, eds.) Bethesda, DHEW/NIH, pp. 7-16

Voellmy R, Leisinger T (1978) Regulation of enzyme synthesis in the arginine biosynthetic pathway of Pseudomonas aeruginosa. J Gen Microbiol 109: 25-35

Voellmy R, Utzinger R (1977) Immunochemical studies on acetylornithine 5-aminotransferase from Pseudomonas aeruginosa. Experientia 33: 1002-3

Voellmy R, Leisinger T (1976) Role of 4-aminobutyrate aminotransferase in the arginine metabolism of Pseudomonas aeruginosa. J Bacteriol 128: 722-9

Voellmy R (1975) Dissertation No. 5500. Zur Regulation des Argininstoffwechsels von Pseudomonas aeruginosa. ETH-Zuerich, Switzerland

Voellmy R, Leisinger T (1975) Dual role for N-2-acetylornithine 5-aminotransferase from Pseudomonas aeruginosa in arginine biosynthesis and arginine catabolism. J Bacteriol 122: 799-809

Voellmy R, Leisinger T (1974) Induction of N-2-acetylornithine-5-aminotransferase in Pseudomonas aeruginosa with arginine. Pathol Microbiol 41: 188-90

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